Lipidomic and microbiome parameters were studied, along with how hydrophobic NEFAs in our aqueous environments may injure immune cells when unbound to their carrier albumin,18,19 which is reduced early in severe AP.20,21 We noted amphipathic, unbound, unsaturated NEFA–phospholipid interactions increase their cellular uptake, causing immune cell mitochondrial injury, inflammatory cell death, and impaired bacterial clearance, thus causing infection during a sterile disease. The gene discussed is ALB; the disease is infection.