Studies have shown that the deletion of transcription factors or transcription disorders can lead to inhibition of tumor proliferation, migration, or invasion.[48, 49, 50] Therefore, depending on the models of molecular docking, we hypothesized that TB‐5 interferes with the binding of the RRM region of NCL to rDNA, which disrupts the regulation of the rRNA transcription process and then inhibits the proliferation and migration of cancer cells. Here, NUCLEOLIN is linked to neoplasm.