Autophagy is essential for maintaining cell homeostasis, which can be inhibited not only by the Ras‐activated PI3K/Akt/mTOR pathway[36, 37] but also by Bcl‐2 blocking the Beclin‐1 pathway.[38] NCL can activate the cellular autophagy pathway by downregulating the autophagy‐related proteins P62 or Bcl‐2.[39] TB‐5 could increase the intracellular protein level of P62 or microtubule–associated protein 1A/1B–light chain 3B (LC3II), suggesting that TB‐5 can increase the mortality of tumor cells via autophagy. The gene discussed is NUCLEOLIN; the disease is neoplasm.