Similarly, Western blot analysis revealed that upregulation of c-PARP, c-caspase 3, c-caspase 8, c-caspase 9, and proapoptotic members BCL-2-related X protein (Bax) and BCL-2-related death agonist (Bad) was greater in the CRC cells treated with unfractionated or F3 bromelain than in those treated with vehicle (Fig 2D and 2E). Here, BAD is linked to colorectal carcinoma.