While Nod2-KO and Ripk2-KO mice are resistant to EAE induced with CFA [33], one study reported that NOD2 played an immunoregulatory role in CFA-induced experimental autoimmune uveitis through T cell–intrinsic, RIPK2-independent NOD2 activity [67]; this curious result still affirms a role for NOD2 in the mycobacterial adjuvant effect. The gene discussed is NOD2; the disease is autoimmune uveitis.