After aerosol infection with 31 CFU H37Rv, the survival of Nod2-KO and Nod2-KO Mincle-KO (double knockout) animals was similar (291 and 281 days, respectively) and significantly reduced compared to WT (over 363 days), while Mincle-KO survival was intermediate (324 days), suggesting that Nod2 deficiency was the driver of hastened mortality in the double knockout. The gene discussed is NOD2; the disease is infection.