In a subsequent M. abscessus study of the same model, Nod2-KO in C57BL/6 mice resulted in defective NO production and bacterial control in the lung, both of which could be rescued with recombinant IFN-β, suggesting a NOD2-IFN-β-NO pathway of M. abscessus control early in infection [68]. Here, IFNB1 is linked to infection.