Both YAP and TAZ mediate Hippo signaling and have functional redundancy in mammals.[42] To examine the role of YAP in DSS‐induced colitis of Smad4−/− mice, we generated VillinCreER;Smad4fl/fl;Yapfl/+;Tazfl/+ mice (Smad4−/−/Yap+/−/Taz+/−). Here, SMAD4 is linked to colitis.