Smad4 has long been documented as a tumor suppressor in the development of colorectal cancer, owing to its key role in mediating TGF‐β signaling to block proliferation or induce apoptosis.[23, 33, 34] Our foregoing results suggest that, in addition to its cytostatic effect, Smad4 may retard inflammation‐induced intestinal tumorigenesis by restricting the inflammatory processes. Here, SMAD4 is linked to colorectal cancer.