While YAP/TAZ is dispensable for the intestinal epithelium in homeostasis,[53] it is required for intestinal regeneration upon injury.[54] In addition, ubiquitously induced expression of YAP in the mouse intestine leads to epithelial dysplasia,[55] whereas it represses metastatic colorectal cancer by reprogramming Lgr5+ cancer stem cells into Klf6+ wound‐healing cells,[56] suggesting a dual role of YAP either as an oncogene or a tumor suppressor in a context‐dependent manner. This evidence concerns the gene LGR5 and intraepithelial neoplasia.