It has been proposed that the spheroid shape of intestinal organoids may suggest a reprogramming into a fetal‐like state to maintain the capacity for regeneration upon damage.[57, 58, 59] A recent study also reported that intestinal tumor cells, when exposed to transient TGF‐β, can revert to an embryonic state in a YAP/TAZ dependent manner and acquire Wnt‐independent growth.[60] We also observed that many fetal genes were upregulated in Smad4‐deficient organoids after TGF‐β stimulation (data not shown). This evidence concerns the gene SMAD4 and intestinal neoplasm.