Some publications report that H3K4me1 enrichment at promoters has been associated with gene repression (Cheng et al., 2014), and MLL3 inactivation decreases H3K4me3 levels at the promoters of metabolism-related genes in normal murine livers (Valekunja et al., 2013) and human liver cancer cells (Ananthanarayanan et al., 2011). This evidence concerns the gene KMT2C and liver cancer.