To determine the genomic binding patterns of MLL3 in HCC, we performed MLL3 chromatin immunoprecipitation (ChIP)-sequencing (ChIP-Seq) analysis in Myc; sgKmt2c (sgKmt2c.1 which generates heterozygous or homozygous indels) and Myc; sgTrp53 liver cancer cell lines. The gene discussed is KMT2C; the disease is hepatocellular carcinoma.