To determine whether MLL3 disruption impacts the local or global chromatin landscape of HCC cells, we performed ChIP-Seq analyses for H3K4 methylation and H3K27 acetylation in six independently derived tumor cell lines: three each for Myc; sgKmt2c and Myc; sgTrp53 (Figure 2C). This evidence concerns the gene MYC and hepatocellular carcinoma.