MYC and cancer: Indeed, Cdkn2a is a cluster 1 locus that, in Myc; sgKmt2c cancer cells, displays significant reduction in (1) expression, (2) H3K4me1/3 and H3K27ac levels, and (3) MLL3 binding at the Cdkn2a promoter compared with Myc; sgTrp53 cells (Figure 2C–D, Figure 4A).