Notably, HCC also harbors mutations in KMT2D (Cleary et al., 2013), while KDM6A/UTX, an H3K27 demethylase within the COMPASS-like complex, has been functionally established as a potent tumor suppressor in pancreatic and liver cancers (Revia et al., 2022). Here, KDM6A is linked to hepatocellular carcinoma.