Genomic alterations found in HCC are highly diverse and are characterized by promoter mutations in TERT (telomerase reverse transcriptase), amplifications, or chromosomal gains encompassing the MYC oncogene, activating hotspot mutations in CTNNB1 (β-catenin), and inactivating mutations and deletions in the TP53 and CDKN2A tumor suppressor genes (2017; Schulze et al., 2015). Here, CDKN2A is linked to hepatocellular carcinoma.