HNF1A-AS1intestine–/– mice showed more susceptibility to DSS colitis in comparison with HNF1A-AS1+/+ and HNF1A-AS1intestine+/–, demonstrating significantly reduced survival (Figure 7H), more severe rectal bleeding (Figure 7I), higher colon weight/length ratio related to induced inflammation (Figure 7J), and larger extent of inflamed tissue as was scored in a blinded histopathologic evaluation of the H&E staining of the colon sections (Figure 7K and Supplemental Figure 8A). This evidence concerns the gene HNF1A and colitis.