CD274 and Sepsis: In accordance with earlier reports (38), we observed a sepsis-specific decrease in Ly6Clo monocytes (scrambled control vs. control: P < 0.001; scrambled control vs. sham: P < 0.05; anti–miR-93-5p vs. control: P < 0.05), while the PD-L1 expression on Ly6Clo monocytes was constant between groups (Supplemental Figure 11, B and C).