TLR8 and Sepsis: In addition, we showed that both endogenous miRNAs, and also viral miRNAs that can bind TLR8, are altered in sepsis (22, 23), that miRNA networks in sepsis are reorganized (24), and that the same sepsis-related miRNAs are dysregulated after splenectomy (25), a condition that increases the risk of sepsis (26).