However, when the 2-12H transgenic BCR was expressed on the lupus-prone MRL/lpr strain, apoptosis normalized and anti-Smith Ab secretion was restored and was linked with increased expression of the prosurvival receptor, BCMA, which binds BAFF and APRIL, relative to nonautoimmune mice (53). Here, TNFRSF17 is linked to systemic lupus erythematosus.