INS and type 1 diabetes mellitus: In line with this, GC anti-insulin B cells, but not non-GC anti-insulin B cells from anti-insulin B cell receptor transgene site-directed to H chain locus (VH125SD.NOD) mice, process and present the unique insulin peptide register recognized by one of the major anti-insulin T cell specificities identified in mice and humans that develop T1D (17–20).