FLT3 and acute myeloid leukemia: In a comprehensive analysis of 244 adult AML-CEBPA, Fasan et al. reported multiple comutations in the CEBPAsm cohort, including FLT3-ITD, NPM1, ASXL1, IDH1/2, and RUNX1 with the majority (70%) of the CEBAPsm mutations located outside of the bZIP region [10].