For example, by processing Notch1 or the amyloid precursor protein (APP), γ-Secretase acts as a central player in developmental processes and dysregulation of the enzyme can lead to the development of devastating diseases including acute T-cell leukemia (T-ALL) and Alzheimer’s disease (AD) [7, 8]. Here, NOTCH1 is linked to T-cell acute lymphoblastic leukemia.