It has been also shown that PRRX1 was a stemness regulator (Shimozaki et al., 2013), involved in adipocyte differentiation (Du et al., 2013), epithelial tumor metastasis and pancreatic regeneration (Fazilaty et al., 2019; Ocaña et al., 2012; Reichert et al., 2013) as well as liver fibrosis (Gong et al., 2017). Here, PRRX1 is linked to Hepatic fibrosis.