Conversely, inhibition of mechanosensitive signalling with Fasudil (35 μM), an inhibitor of ROCK1 and ROCK2 (Zhou et al., 2013), induced PRRX1 TFs mRNA expression in both control and IPF fibroblasts grown on glass/stiff substrate (Figure 3C). The gene discussed is PRRX1; the disease is idiopathic pulmonary fibrosis.