We observed that PRRX1 siRNA-mediated inhibition was associated with an increase of PPM1A, a phosphatase member of the PP2C protein family, at both mRNA and protein levels compared to control and IPF fibroblasts treated with control siRNA (Figure 5F and Figure 5—figure supplement 4). Here, PRRX1 is linked to idiopathic pulmonary fibrosis.