Notably, PRRX1/Prrx1 expression was maintained in fibroblast subtypes enriched during fibrosis, including the Lrrc5pos/ Cthrc1pos population in the mouse bleomycin model, ACTA2pos myofibroblasts, PLIN2pos lipofibroblast-like cells, and HAS1hi fibroblasts in IPF. This evidence concerns the gene PRRX1 and idiopathic pulmonary fibrosis.