To confirm and study further these results obtained with Prrx1 ASO, it will be interesting to perform in vivo CRE-mediated conditional and inducible loss of Prrx1 (Feldmann et al., 2021) in the different mesenchymal lung cell lineages expressing this transcription factor in the bleomycin model of lung fibrosis as discussed above. Here, PRRX1 is linked to pulmonary fibrosis.