TNC and pulmonary fibrosis: While our in vitro findings in adult Human lung fibroblasts showed that PRRX1 inhibition mainly impacted ACTA2 expression levels, Prrx1 ASO treatment in the bleomycin mouse model of lung fibrosis also inhibited the deposition of ECM proteins such as Collagen 1, Fibronectin, Tenascin C, and Elastin.