NT5E and neoplasm: Consistent with the observed decrease in intracellular NAD pools, and the importance of NAD for glycolysis (Hopp, 2019; Luengo et al., 2021), we found that CD73-deficient tumor cells also displayed impaired maximal glycolytic capacity following oligomycin treatment, which inhibits ATP synthase and forces cells to redirect pyruvate to lactate conversion via glycolysis (Luengo et al., 2021).