Cluster-3 cancer cells, predominantly composed of cancer cells in co-culture, showed lower expression of epithelial genes (KRT19, EPCAM, CDH1) and higher expression of mesenchymal genes (SPARC, TIMP1, VIM, MMP2) and gene sets (Hallmark EMT) reflecting a (partial) epithelial-to-mesenchymal transition (EMT) (Figures 3G, H). Here, SPARC is linked to cancer.