A number of previous studies have clearly demonstrated that BH can be used to mechanically fractionate different types of soft tissues (liver, kidney, brain, prostate, etc) and cancer cells (renal carcinoma, breast cancer, colorectal cancer, prostate cancer, etc) without causing any significant thermal damage (14–23) as well as can promote immunogenic cell death of cancer cells via TNF-induced necrosis signalling pathway (21). This evidence concerns the gene TNF and cancer.