Reduced expression of CD4, CD25, and FOXP3 is a major genetic defect in SLE and MSCs can promote CD4+, CD25+, and FOXP3+ inducible Treg cells in SLE peripheral blood mononuclear cells (PBMCs) by releasing Transforming Growth Factor Beta 1 (TGFβ1) (101). The gene discussed is CD4; the disease is systemic lupus erythematosus.