This suggests that MSCs can modulate the level of pre-miR-34a m6A modification through METTL3/IGF2BP3 to improve the stability of pre-miR-34a, promote miR-34a-5p secretion, maintain intestinal function, and protect the integrity of the intestinal barrier Maintaining the integrity of the intestinal barrier and intestinal function is also very important in the treatment of IBD, and MSCs play a therapeutic role in IBD by regulating the epigenetic modification of pre-miR-34A through METTL3 and IGF2BP3 (69). Here, METTL3 is linked to inflammatory bowel disease.