CXCR4 and acute myeloid leukemia: IVM of calvarium bone marrow tracked the migratory behavior of acute myeloid leukemia (AML) cells in comparison to T cell acute lymphoblastic leukemia (T-ALL), and demonstrated distinct traits of the lineages in their response to chemotherapy and CXCR4 antagonism, highlighting the importance of carefully evaluating cancer traits in vivo for each tumor type (171).