In addition, the dysfunctional complex of phosphatase and tensin homolog deleted on chromosome 10 (PTEN) with the cystic fibrosis (CF) transmembrane conductance regulator (CFTR), which is associated with the pathogenesis of cystic fibrosis, increases the production of succinate and IRG1-ITA (47). This evidence concerns the gene ACOD1 and cystic fibrosis.