The effects of RAGE and its ligands can be amplified in various diseases, such as vascular disease, diabetes, cancer, hepatic fibrosis, chronic airway disease, and neurodegenerative disease (Han et al., 2011; Zhao et al., 2014; Xia et al., 2015; Chen et al., 2016). The gene discussed is AGER; the disease is neurodegenerative disease.