Previous studies correlated the engagement of RAGE with various ligands with the pathogenesis of several fibrotic diseases in different organs, including hepatic fibrosis, idiopathic pulmonary fibrosis, myocardial infarction, and diabetic cardiomyopathy (Ku et al., 2015; Kyung et al., 2014; T. W; Lee et al., 2014; Xia et al., 2015; Yamagishi and Matsui, 2015; Zhao et al., 2014). This evidence concerns the gene AGER and Hepatic fibrosis.