Liver cancer is the result of structural abnormalities in the blood vessels of the liver, and this angiogenesis is driven by the overexpression of hypoxia-inducible factor 1-α (Hif1-α) and vascular endothelial growth factor (VEGF), in addition, protein kinase B (Akt) are also compromised in liver cancer. This evidence concerns the gene VEGFA and liver cancer.