IRS2 and metabolic dysfunction-associated steatotic liver disease: Hepatic gene expression analysis shown in Figure 2 revealed that the hepatic mRNA expression of SREBP-1-c was markedly (p < 0.05) upregulated, while hepatic PPAR-α and IRS-2 mRNA expressions levels were markedly (p < 0.05) downregulated in the NAFLD rats relative to the control group.