At present researchers believe that the onset of AD is the result of a combination of multiple factors including amyloid plaques (Aβ plaque), neurofibrillary tangles (tau protein), vital mitochondrial dysfunction, oxidative stress, and inflammation pathways in brain neurons (Serý et al., 2013; Medala et al., 2021; Patro et al., 2021; Gowda et al., 2022). Here, MAPT is linked to Alzheimer disease.