According to Figure 11, which shows the cluster analysis of keyword co-occurrence, the most popular keywords related to mitochondrial dysfunction in AD included “oxidative stress,” “amyloid beta,” “amyloid precursor protein,” “cytochrome-c-oxidase,” and “autophagy.” Reading the Tenth figure (timing analysis of keyword co-occurrence), indicates that “calcium homeostasis,” “precursor protein,” “amyloid beta,” “autophagy,” “dynamics,” “abnormal interaction,” and “unfolded protein response (UPR)” were popular hot spots in order of time (from 2012). The gene discussed is APP; the disease is Alzheimer disease.