MAPT and early-onset autosomal dominant Alzheimer disease: Their research named “Amyloid Beta and Phosphorylated Tau-Induced Defective Autophagy and Mitophagy in Alzheimer’s Disease” highlights recent development of A and P-Tau-induced defective autophagy and mitophagy in AD and summarizes several aspects of mitochondrial dysfunction, including abnormal mitochondrial dynamics, defective mitochondrial biogenesis, reduced ATP, increased free radicals and lipid peroxidation, and decreased COX activity and calcium dyshomeostasis in AD pathogenesis (Reddy and Oliver, 2019).