AHR and Ito hypomelanosis: In this study, 71 DEPs were reported in patient group with higher levels of PAH and IPA toxicity list of these DEPs was predicted to be involved in Aryl Hydrocarbon Receptor (AhR) Signalling, Xenobiotic Metabolism Signalling, Hypoxia-Inducible Factor Signalling, NRF2-mediated Oxidative Stress Response, Mitochondrial Dysfunction and Oxidative Phosphorylation.