In fact, we have observed increased retention of histone proteins (H1-3, H1-4, H1-7, H2BC19P, H2BC11, H2BC12, H2BS1) in the spermatozoa of idiopathic infertile patients implying improper nuclear remodelling (Torres-Flores and Hernandez-Hernandez, 2020). This evidence concerns the gene H2BC12 and Infertility.