KCs are activated by cholesterol through various mechanisms, including the liver x receptor (LXR) α (NR1H3) and LXRβ (NR1H2), which are critical nuclear receptors involved in cholesterol absorption, excretion, metabolism, transcriptional regulation, and cholesterol homeostasis regulation, and are also associated with hypertriglyceridemia and liver steatosis (Wang and Tontonoz, 2018); (Russo-Savage and Schulman, 2021). The gene discussed is NR1H2; the disease is fatty liver disease.