Several studies have shown that specific strains of probiotics, such as Lactobacillus paracasei (Sohn et al., 2015) and Lactobacillus pentosus strain S-PT84 (Sakai et al., 2020), can mitigate hepatic steatosis by inducing the polarization of KCs and macrophages towards the M2-like phenotype in the NASH model. This evidence concerns the gene TBCE and metabolic dysfunction-associated steatohepatitis.