NLRP3 and metabolic dysfunction-associated steatohepatitis: Hepatocyte pyroptosis, an inflammatory cell death resulting from caspase 1-mediated activation of inflammatory corpuscles, such as NLRP3 and AIM2 (Shojaie et al., 2020); (de Carvalho Ribeiro and Szabo, 2022), has a complex relationship with NASH.