1,435 patients with IBD were matched with 1,588 individuals without IBD. Subjects with IBD had higher incidences of IHD than matched controls (12.1% vs. 5.5%; p < .001). The risk of IHD reached a peak level in patients aged 18–35 years in IBD compared with non-IBD subjects (CD:OR: 6.33, 95% CI: 3.29–12.16; UC: OR: 3.00, 95% CI: 1.18–7.60). CRP was positively related with the risk of IHD (OR, 1.02; 95% CI: 1.01–1.03) in individuals with CD. This evidence concerns the gene CRP and myocardial ischemia.