NOD2 and coronary atherosclerosis: Indeed, it has been observed that some nucleotide-binding oligomerization domain-containing protein 2 (NOD2)/CARD15 polymorphisms (2 missense mutations: ARG702TRP, GLY908ARG; 1 frameshift mutation: 1,007 fs) implicated in the regulation of CD were associated also with the development of coronary atherosclerosis (28–30).