We propose that low expression of LINC00426 is potentially related with immunosuppressive TIMEs with high fractions of immune cell populations associated with cancer progression and immune evasion, such as mast cells, M0 and M2 macrophages (Stanton and Disis, 2016; Bense et al., 2017) in PAM50 LB BRCA, which potentially could be related with deficiencies in the host’s anti-tumor immune response. Here, LINC00426 is linked to cancer.