Chen et al. demonstrated that the lncRNA LNMAT1 activates the expression of CCL2 through epigenetic pathways and hnRNPL binding to the promotor region of CCL2, which results in the recruitment of tumor-associated macrophages to the TIME of bladder cancer, promoting lymphatic metastasis via VEGF-C excretion (Chen C. et al., 2018). This evidence concerns the gene HNRNPL and urinary bladder carcinoma.