When KGM+KSM was combined with AFP to build the ROC curve, the AUC values for distinguishing HCC from NC and LC improved slightly when compared to the KGM+KSM panel, reaching 0.99 ± 0.02 and 0.76 ± 0.17, respectively (Figure 8E). This evidence concerns the gene AFP and laryngotracheoesophageal cleft.