GCG and colitis: GLP-2 is an intestine-derived hormone that promotes intestinal growth, digestion, absorption, barrier function, and blood flow in healthy animals, prevents damage, and promotes repair in preclinical models of colitis, and after massive small bowel resection (Li and Weigmann, 2022), GLP-2 expression is reduced in UC due to the destruction or inhibition of intestinal endocrine L cells in the inflammatory state (Zatorski et al., 2019).