Ivory et al. (2008) investigated the mechanism of anti-inflammatory effect of GLP-2 through an IL-10-deficient colitis mouse model and showed that the anti-inflammatory effect of GLP-2 was not dependent on IL-10 but was attributed to GLP-2 antagonizing IL-6-mediated STAT3 signaling, thereby inhibiting intestinal inflammation, consistent with the results of this experiment. The gene discussed is STAT3; the disease is colitis.