It is worth affirming that GLP-2 is beneficial for intestinal inflammation, flora environment, and metabolism of blood glucose, and since GLP-2 is a short peptide chain containing only 33 amino acids and is very easy to obtain chemically, in future, exogenous supplementation of the protective secretory factor GLP-2 could then provide new therapeutic ideas for UC and its associated metabolic diseases. Here, GCG is linked to metabolic disease.