Currently, cognitive behavioral therapy (sleep restriction, stimulus control, cognitive therapy, relaxation therapy, and sleep hygiene) is the preferred treatment for insomnia, and if it is not effective, then pharmacotherapy (benzodiazepine-receptor agonists, antidepressants, orexin antagonists, melatonin agonists, and anticonvulsant: gabapentin) is the preferred treatment for insomnia. This evidence concerns the gene HCRT and insomnia.