Compared with the adrenal CS patients, those with CD exhibited higher basal serum cortisol (median, 37.40 μg/dL vs. 27.90 μg/dL; p = 0.005), basal plasma ACTH (median, 115.00 pg/mL vs. 5.00 pg/mL; p < 0.001), and 24-h UFC (median, 579.60 μg/24 h vs. 226.60 μg/24 h; p = 0.003). This evidence concerns the gene POMC and Cowden syndrome 1.