OPA1 and Leber hereditary optic neuropathy: Alteration in OPA1 expression in BBSOAS models is particularly interesting considering that OPA1 haploinsufficiency is the major genetic pathological mechanism of autosomal-dominant optic atrophy in humans (Lenaers et al., 2021) and that optic atrophy in BBSAOS patients is among the most common clinical features.