NR2F1 and Down syndrome: Altered NR2F1 expression has also been reported in Down syndrome human-derived neural cells (Bhattacharyya et al., 2009; Halevy et al., 2016) as well as in neurodegenerative disorders, including in mouse models of Alzheimer's and Parkinson's diseases (Walter et al., 2021; Zheng et al., 2020).