Although there was no statistically significant difference between Cerro 87(pACYC184) and Cerro 87(pWHU3638), the DNA replication rate of PT1 from Cerro 87(pWHU3638) was consistently slower than that of PT1 from Cerro 87(pACYC184) from 30 minutes after infection, implying an additive defense effect due to the coexistence of Dnd and Ssp R-M systems. Here, ZNF77 is linked to infection.