Transducin-like enhancer of split 1 (TLE1), a human orthologue of the Drosophila developmental corepressor Groucho (Gro), acts as an anti-proliferative factor (Zahavi et al., 2017), and TLE family members have been linked to human cancers (Kokabu et al., 2017; Dali et al., 2018). The gene discussed is TLE1; the disease is cancer.