TLE1 and TLE3 are both implicated in cancer; TLE1, for example, promotes glioblastoma propagation (Dali et al., 2018) and TLE3 stimulates cell division by suppressing myogenic differentiation via transcriptional repression of the master regulator MyoD (Kokabu et al., 2017). Here, TLE3 is linked to glioblastoma.