Additional mutations in DCTN1, mostly in the CAP-Gly domain important for binding to microtubules and initiating retrograde axonal transport (5, 6), have been identified that lead to ALS (63, 64) and Perry syndrome (65), a rare disease characterized by parkinsonism, psychiatric manifestations, central hypoventilation, and weight loss. Here, DCTN1 is linked to amyotrophic lateral sclerosis.