Although mitochondrial trafficking was not altered in motor nerves in a third-instar larva Drosophila model of C9orf72 ALS (142), another recent study found reduced mitochondrial trafficking in aged, induced pluripotent stem cell–derived (iPS-derived) motor neurons and adult Drosophila neurons (143). Here, C9orf72 is linked to amyotrophic lateral sclerosis.