Pomper and co-workers demonstrated the PSMA-targeted tumor uptake of a 27.3 kDa generation 4 (G4) polyamidoamine dendrimer, G4(MP-KEU), conjugated with ACUPA ligands, that showed very high PSMA-targeted tumor accumulation compared to the control dendrimer, G4(Ctrl), of 23.2 kDa without any ACUPA ligands (Figure 12) [68]. The gene discussed is FOLH1; the disease is neoplasm.