In contrast to G4 polyamidoamine dendrimers, Simanek and co-workers demonstrated a comparative in vivo analysis of PSMA-targeted G1, G3, and G5 triazine dendrimers that provides more clarity on how the size of the nanocarriers strongly influences the in vivo pharmacokinetics of both active and passive tumor uptake [5]. This evidence concerns the gene FOLH1 and neoplasm.