A similar pattern of tumor accumulation of PLA-b-PEG NPs was demonstrated by Pomper and co-workers beyond 24 h post-injection by using small molecule-based PSMA-targeting ligands (ACUPA) in a mice model bearing dual xenografts of PSMA+ PC3-Pip and PSMA- PC3-Flu tumors (Figure 6A) [51]. The gene discussed is FOLH1; the disease is neoplasm.