The CCR4 interaction with CCL12 activates intracellular signaling that activates various pathways such as NF-Kb, RAS-MAPK, JAK-STAT, P13K-AKT-mTOR, and PLC-Ca2+, which can regulate angiogenesis, tumor cell proliferation, and apoptosis inhibition. The gene discussed is CCR4; the disease is neoplasm.