TARDBP and amyotrophic lateral sclerosis: In most cases of amyotrophic lateral sclerosis, there is no family history associated, but in about 10% of cases, a dominantly inherited autosomal mutation occurs in distinct genes, such as in superoxide dismutase 1 (SOD1), C9orf72, and TAR DNA-binding protein 43 (TDP-43) genes [35].