TARDBP and amyotrophic lateral sclerosis: Several misfolded proteins are also associated with amyotrophic lateral sclerosis, such as SOD1, TDP-43, ubiquilin-2, and p62, which are produced through the unconventional repeat associated non-ATG translation of the repeat expansion in C9ORF72, which can promote the inhibition of essential cellular functions, leading to neuronal loss [84].