Recently, Tapella and collaborators analyzed the cellular secretome and demonstrated that 4-PBA treatment of an immortalized astrocytic cell line (3Tg-iAstro cells) from 3xTg-AD mice (Triple-Transgenic model (3xTg-AD) harboring PS1(M146V), APP(Swe), and tau(P301L) transgenes), a popular model of Alzheimer’s disease (AD), rescued the presence of proteins responsible for extracellular matrix formation [2]. The gene discussed is APP; the disease is Alzheimer disease.