Of relevance, recent results of a meta-analysis of over 1000 pediatric high-grade gliomas and DIPG cases identified amplifications in cell cycle genes including CCND1, CDK4 and CDK6 among the genetic aberrations in subclonal populations of DIPG [26,27], suggesting that cell cycle drivers may be potential targets in this incurable disease [27]. This evidence concerns the gene CDK4 and central nervous system cancer.