Our previous study showed that TP5 can inhibit the stemness of colorectal cancer stem cells via nicotinic acetylcholine receptors (nAchRs) [40], and the TP5-mediated changes in macrophage function were further verified here also by the acetylcholine receptor antagonist D-Tubocurarine chloride pentahydrate (TUB). Here, TMPO is linked to colorectal cancer.