The study of Yalin Wang et al. showed that after 12 weeks of receiving chronic mill stress (CMS) in adult male SD rats, [18F] DPA-714 micro PET showed a significant increase in the uptake of radioactivity in the hippocampus, at the same time they also detected an increase in NLRP3 inflammasome and some inflammatory mediators in the hippocampus after chronic stress and found that minocycline treatment can alleviate the depressive- and anxiety-like behavior and neuro-inflammation induced by chronic stress [16]. Here, NLRP3 is linked to Anxiety.