The Parkin protein encoded by the gene acts as ubiquitin E3 ligand, α-synuclein, and DJ-1 can induce PINK, LRRK2, HTRA2, etc. Furthermore, mutations in the complex I subunit, 12S rRNA [141], and POLG encoded by mtDNA also contribute to Parkinson’s disease. This evidence concerns the gene PARK7 and Parkinson disease.