These findings are of great significance in the context of CRC, considering that APC mutations are an early and critical driver in the stepwise progression from adenoma to carcinoma [109], and also because the intestinal stem cell niche provides large amounts of Wnt ligands and amplifiers, which cooperates with intrinsic alterations of Wnt pathway members for the onset and progression of CRC [110]. Here, APC is linked to carcinoma.