TP53 and glioma: In another study, Kowalczyk et al. [100] reported the anticancer potential of root extracts of Menyanthes trifoliate containing SyA with an induction of apoptosis mediated by G2/M phase cell cycle arrest and changes in the expression of Bax, Bcl-2, cas-3, and p53 as well as a reduction in the mitochondrial membrane potential in IV glioma cells.