The ROC analysis showed that among the evaluated cardiac biomarkers and non-coding RNAs between cases of heart failure and those without heart failure, serum lncRNA MEG3 demonstrated the highest AUC (0.92), specificity (96.7%), and sensitivity (87.2%), followed by mir361showing AUC (0.913), specificity (100%), sensitivity (60%), and finally lncRNA-Chaer the AUC was (0.852), the specificity (100%), and the sensitivity (70.8%). Here, MEG3 is linked to heart failure.