VEGFA and neoplasm: The key signalling process in the development of the tumour vasculature is the hypoxia-induced stimulation of Hypoxia Inducible Factor 1 alpha (HIF 1-α), resulting in the suppression of anti-angiogenic factors, such as trombospondin-1 and angiostatin, whilst simultaneously promoting the production of Vascular Endothelial Growth Factors (VEGF) and basic fibroblast growth factor (bFGF) [18].