In addition, LBPs inhibited the upregulation of GRK2, reduced the apoptosis of cardiomyocytes, and partially restored the imbalance of ischemia/reperfusion-induced mitochondrial division/fusion by regulating the expressions of Drp1, Opa1, and Mfn2 in AKT/eNOS signaling pathway in the ischemia/reperfusion injury model. Here, OPA1 is linked to ischemia.