CP and infection: AEC-CCo-CP-buLf-NCs were efficiently distributed in the blood, intestine, liver, and spleen; moreover, AEC-CCo-CP-buLf-NCs exhibited effective antimalarial action evidenced by a significant decrease in parasite load in erythrocytes and reduced damage in the liver and spleen as seen with chloroquine, the antimalarial drug of reference, which was included as a positive control on day 12 post-infection.