TNF and polycystic ovary syndrome: Mice that were treated with a high-fat diet (HFD) showed a decrease in body weight and downregulation of Tumor Necrosis Factor α (TNF-α) and Interleukin -1β after treatment with L. sakei [56] Female C57BL/6 mice, when fed with Lactobacillus JBD301, increased the fecal excretion and the gut fluid, inhibiting the weight gain, which is commonly seen in PCOS women [57].