In this finding, we further elucidated that m6A YTHDF1 mediates the translation of FTH increased and altered by disorder of METTL3 and, thereby, accelerates tumorigenesis in lung cancer cells, meaning FTH is an essential YTHDF1 target gene in lung cancer, obviously, in an m6A-dependent manner. The gene discussed is FTH1; the disease is lung cancer.